Clinical significance versus statistical significance

Statistical Significance versus Clinical Significance in Clinical Trials

Statistical significance and clinical significance.

Statistical versus Practical Significance

The clinical significance of statistical significance.

Modern clinical trials provide the evidence for most therapeutic advances, and that evidence, expressed in a statistical format, is used to draw inferences about a population from the study's results. Clinician judgment translates these inferences for best individual patient care, but many clinicians struggle with the statistical interpretation of trial results. This review provides a clinical ...

Developmental Fluoride Neurotoxicity: Clinical Importance versus Statistical Significance

We were interested to read the article by Choi et al. (2012), who investigated the effects of increased fluoride exposure and delayed neuro behavioral develop ment by reviewing published studies and performing a meta-analysis. Of the 39 studies identified, the authors considered 27 to be eligible. Choi et al. reported a mean difference in IQ (intelli gence quotient) score between exposed and re...